Research Topic on Metabolism, Tumor Microenvironment, and Radiotherapy
A collaborative Research Topic in Frontiers in Oncology, “Metabolism at the Crossroads of DNA Repair, Immune Response, and Tumor Microenvironment in Radiotherapy,” brings together perspectives from cancer metabolism, radiation biology, tumor immunology, and tumor microenvironment research.
The Research Topic is jointly edited by Mostafa Yazdi, Ph.D., Missouri University of Science and Technology; Johann Matschke, Habilitation, Essen University Hospital, Germany; and Edikan Ogunnaike, Ph.D., Emory University, United States.
The collection focuses on the increasingly important role of metabolic reprogramming in shaping tumor responses to radiotherapy, particularly through its interconnected effects on the tumor microenvironment, DNA damage response, and anti-tumor immunity. Metabolic adaptations, including those associated with hypoxia and radiation-induced metabolic changes, can influence cancer cell survival, DNA repair, immune-cell function, and therapeutic resistance.
The Research Topic brings together research examining how cancer metabolism, the tumor microenvironment, and radiotherapy interact to determine treatment outcomes. Areas of interest include metabolic regulation of DNA damage response, radiation-induced metabolic reprogramming, hypoxia-associated radioresistance, metabolic control of the tumor immune microenvironment, biomarkers of metabolic adaptation, and therapeutic strategies targeting metabolism to enhance radiosensitivity.
The strong interest in this Research Topic highlights the growing recognition that metabolism is not simply a consequence of tumor progression or treatment, but a critical regulator of the tumor microenvironment and response to radiotherapy. Understanding these interconnected mechanisms may provide new opportunities to overcome treatment resistance and develop more effective radiation-based cancer therapies.
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